Publications

2021

Woythe, L., Tito, N.B., Albertazzi, L., 2021. A quantitative view on multivalent nanomedicine targeting. Adv. Drug Deliv. Rev. 169, 1-21 https://doi.org/10.1016/j.addr.2020.11.010.
Feiner-Gracia, N., Glinkowska Mares, A., Buzhor, M., Rodriguez-Trujillo, R., Samitier, J., Amir, R.J., Pujals, S., Albertazzi, L., 2021. Real-time Ratiometric Imaging of Micelles Assembly State in a Microfluidic Cancer-on-a-chip. ACS Appl. Bio Mater. 2021, 4, 1, 669–681 https://doi-org.sire.ub.edu/10.1021/acsabm.0c01209 and 2020 bioRxchiv https://doi.org/10.1101/2020.03.08.978783

2020

Andrian, T., Bakkum, T., van Elsland, D.M., Bos, E., Koster, A.J, Albertazzi, L., van Kasteren, S.I., Pujals, S., 2020. Super-resolution correlative light-electron microscopy using a click-chemistry approach for studying intracellular trafficking. Methods Cell Biol. https://doi.org/10.1016/bs.mcb.2020.09.001.
Fuentes, E., Boháčová, K., Fuentes-Caparrós, A.M., Schweins, R., Draper, E.R., Adams, D.J., Pujals, S., Albertazzi, L., 2020a. PAINT-ing Fluorenylmethoxycarbonyl (Fmoc)-Diphenylalanine Hydrogels. Chemistry – A European Journal n/a. https://doi.org/10.1002/chem.202001560
Fuentes, E., Gerth, M., Berrocal, J.A., Matera, C., Gorostiza, P., Voets, I.K., Pujals, S., Albertazzi, L., 2020b. An Azobenzene-Based Single-Component Supramolecular Polymer Responsive to Multiple Stimuli in Water. J. Am. Chem. Soc. 142, 10069–10078. https://doi.org/10.1021/jacs.0c02067
Delcanale, P., Albertazzi, L., 2020. DNA-PAINT super-resolution imaging data of surface exposed active sites on particles. Data in Brief 30, 105468. https://doi.org/10.1016/j.dib.2020.105468
Feiner Gracia, N., 2020. Reaching the tumour: nanoscopy study of nanoparticles in the biological environment. Eindhoven: Technische Universiteit Eindhoven.

2019

Riera, R., Feiner-Gracia, N., Fornaguera, C., Cascante, A., Borrós, S., Albertazzi, L., 2019. Tracking the DNA complexation state of pBAE polyplexes in cells with super resolution microscopy. Nanoscale 11(38):17869-17877. https://doi.org/10.1039/C9NR02858G
Pujals, S., Albertazzi, L., 2019. Super-resolution Microscopy for Nanomedicine Research. ACS Nano 13(9):9707-9712. https://doi.org/10.1021/acsnano.9b05289
Bastings, M.M.C., Hermans, T.M., Spiering, A.J.H., Kemps, E.W.L., Albertazzi, L., Kurisinkal, E.E., Dankers, P.Y.W., 2019. Quantifying Guest-Host Dynamics in Supramolecular Assemblies to Analyze Their Robustness. Macromol Biosci 19, e1800296. https://doi.org/10.1002/mabi.201800296
Post, R. a. J., van der Zwaag, D., Bet, G., Wijnands, S.P.W., Albertazzi, L., Meijer, E.W., van der Hofstad, R.W., 2019. A stochastic view on surface inhomogeneity of nanoparticles. Nat Commun 10, 1663. https://doi.org/10.1038/s41467-019-09595-y
Feiner-Gracia, N., Olea, R.A., Fitzner, R., El Boujnouni, N., van Asbeck, A.H., Brock, R., Albertazzi, L., 2019. Super-resolution Imaging of Structure, Molecular Composition, and Stability of Single Oligonucleotide Polyplexes. Nano Lett. 19, 2784–2792. https://doi.org/10.1021/acs.nanolett.8b04407
Kolpe, A., Arista-Romero, M., Schepens, B., Pujals, S., Saelens, X., Albertazzi, L., 2019. Super-resolution microscopy reveals significant impact of M2e-specific monoclonal antibodies on influenza A virus filament formation at the host cell surface. Sci Rep 9, 4450. https://doi.org/10.1038/s41598-019-41023-5
Pujals, S., Feiner-Gracia, N., Delcanale, P., Voets, I., Albertazzi, L, 2019. Super-Resolution Microscopy as a Powerful Tool to Study Complex Synthetic Materials. Nat Rev Chem 2, 68–84. https://doi.org/10.1038/s41570-018-0070-2
Uroz, M., Garcia-Puig, A., Tekeli, I., Elosegui-Artola, A., Abenza, J.F., Marín-Llauradó, A., Pujals, S., Conte, V., Albertazzi, L., Roca-Cusachs, P., Raya, Á., Trepat, X., 2019. Traction forces at the cytokinetic ring regulate cell division and polyploidy in the migrating zebrafish epicardium. Nat Mater 18, 1015–1023. https://doi.org/10.1038/s41563-019-0381-9
Cremers, G.A.O., Rosier, B.J.H.M., Riera Brillas, R., Albertazzi, L., de Greef, T.F.A., 2019. Efficient Small-Scale Conjugation of DNA to Primary Antibodies for Multiplexed Cellular Targeting. Bioconjug. Chem. 30, 2384–2392. https://doi.org/10.1021/acs.bioconjchem.9b00490
De Coen, R., Nuhn, L., Perera, C., Arista-Romero, M., Risseeuw, M.D.P., Freyn, A., Nachbagauer, R., Albertazzi, L., Van Calenbergh, S., Spiegel, D.A., Peterson, B.R., De Geest, B.G., 2019. A synthetic rhamnose glycopolymer cell surface receptor for endogenous antibody recruitment. Biomacromolecules. https://doi.org/10.1021/acs.biomac.9b01483

2018

Ardizzone, A., Kurhuzenkau, S., Illa‐Tuset, S., Faraudo, J., Bondar, M., Hagan, D., Stryland, E.W.V., Painelli, A., Sissa, C., Feiner, N., Albertazzi, L., Veciana, J., Ventosa, N., 2018. Nanostructuring Lipophilic Dyes in Water Using Stable Vesicles, Quatsomes, as Scaffolds and Their Use as Probes for Bioimaging. Small 14, 1703851. https://doi.org/10.1002/smll.201703851
Liu, Y., Pujals, S., Stals, P.J.M., Paulöhrl, T., Presolski, S.I., Meijer, E.W., Albertazzi, L., Palmans, A.R.A., 2018. Catalytically Active Single-Chain Polymeric Nanoparticles: Exploring Their Functions in Complex Biological Media. J. Am. Chem. Soc. 140, 3423–3433. https://doi.org/10.1021/jacs.8b00122
Krivitsky, A., Polyak, D., Scomparin, A., Eliyahu, S., Ofek, P., Tiram, G., Kalinski, H., Avkin-Nachum, S., Feiner Gracia, N., Albertazzi, L., Satchi-Fainaro, R., 2018a. Amphiphilic poly(α)glutamate polymeric micelles for systemic administration of siRNA to tumors. Nanomedicine: Nanotechnology, Biology and Medicine 14, 303–315. https://doi.org/10.1016/j.nano.2017.10.012
Casellas, N.M., Pujals, S., Bochicchio, D., Pavan, G.M., Torres, T., Albertazzi, L., García-Iglesias, M., 2018. From isodesmic to highly cooperative: reverting the supramolecular polymerization mechanism in water by fine monomer design. Chem. Commun. 54, 4112–4115. https://doi.org/10.1039/C8CC01259H
Patiño, T., Feiner-Gracia, N., Arqué, X., Miguel-López, A., Jannasch, A., Stumpp, T., Schäffer, E., Albertazzi, L., Sánchez, S., 2018. Influence of Enzyme Quantity and Distribution on the Self-Propulsion of Non-Janus Urease-Powered Micromotors. J. Am. Chem. Soc. 140, 7896–7903. https://doi.org/10.1021/jacs.8b03460
van Elsland, D.M., Pujals, S., Bakkum, T., Bos, E., Oikonomeas‐Koppasis, N., Berlin, I., Neefjes, J., Meijer, A.H., Koster, A.J., Albertazzi, L., van Kasteren, S.I., 2018. Ultrastructural Imaging of Salmonella–Host Interactions Using Super‐resolution Correlative Light‐Electron Microscopy of Bioorthogonal Pathogens. Chembiochem 19, 1766–1770. https://doi.org/10.1002/cbic.201800230
Delcanale, P., Miret-Ontiveros, B., Arista-Romero, M., Pujals, S., Albertazzi, L., 2018. Nanoscale Mapping Functional Sites on Nanoparticles by Points Accumulation for Imaging in Nanoscale Topography (PAINT). ACS Nano 12, 7629–7637. https://doi.org/10.1021/acsnano.7b09063

2017

Duro‐Castano, A., Nebot, V.J., Niño‐Pariente, A., Armiñán, A., Arroyo‐Crespo, J.J., Paul, A., Feiner‐Gracia, N., Albertazzi, L., Vicent, M.J., 2017. Capturing “Extraordinary” Soft-Assembled Charge-Like Polypeptides as a Strategy for Nanocarrier Design. Advanced Materials 29, 1702888. https://doi.org/10.1002/adma.201702888
Labernadie, A., Kato, T., Brugués, A., Serra-Picamal, X., Derzsi, S., Arwert, E., Weston, A., González-Tarragó, V., Elosegui-Artola, A., Albertazzi, L., Alcaraz, J., Roca-Cusachs, P., Sahai, E., Trepat, X., 2017. A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion. Nat. Cell Biol. 19, 224–237. https://doi.org/10.1038/ncb3478
Feiner-Gracia, N., Beck, M., Pujals, S., Tosi, S., Mandal, T., Buske, C., Linden, M., Albertazzi, L., 2017b. Super-Resolution Microscopy Unveils Dynamic Heterogeneities in Nanoparticle Protein Corona. Small 13. https://doi.org/10.1002/smll.201701631
Feiner-Gracia, N., Buzhor, M., Fuentes, E., Pujals, S., Amir, R.J., Albertazzi, L., 2017a. Micellar Stability in Biological Media Dictates Internalization in Living Cells. J. Am. Chem. Soc. 139, 16677–16687. https://doi.org/10.1021/jacs.7b08351
Oria, R., Wiegand, T., Escribano, J., Elosegui-Artola, A., Uriarte, J.J., Moreno-Pulido, C., Platzman, I., Delcanale, P., Albertazzi, L., Navajas, D., Trepat, X., García-Aznar, J.M., Cavalcanti-Adam, E.A., Roca-Cusachs, P., 2017. Force loading explains spatial sensing of ligands by cells. Nature 552, 219–224. https://doi.org/10.1038/nature24662
Onzen, A.H.A.M. van, Albertazzi, L., Schenning, A.P.H.J., Milroy, L.-G., Brunsveld, L., 2017. Hydrophobicity determines the fate of self-assembled fluorescent nanoparticles in cells. Chem. Commun. 53, 1626–1629. https://doi.org/10.1039/C6CC08793K
Pujals, S., Tao, K., Terradellas, A., Gazit, E., Albertazzi, L., 2017. Studying structure and dynamics of self-assembled peptide nanostructures using fluorescence and super resolution microscopy. Chem. Commun. 53, 7294–7297. https://doi.org/10.1039/C7CC02176C
Caballero, D., Blackburn, S.M., Pablo, M. de, Samitier, J., Albertazzi, L., 2017. Tumour-vessel-on-a-chip models for drug delivery. Lab Chip 17, 3760–3771. https://doi.org/10.1039/C7LC00574A

2016

da Silva, R.M.P., van der Zwaag, D., Albertazzi, L., Lee, S.S., Meijer, E.W., Stupp, S.I., 2016. Super-resolution microscopy reveals structural diversity in molecular exchange among peptide amphiphile nanofibres. Nat Commun 7, 11561. https://doi.org/10.1038/ncomms11561
De Koker, S., Cui, J., Vanparijs, N., Albertazzi, L., Grooten, J., Caruso, F., De Geest, B.G., 2016. Engineering Polymer Hydrogel Nanoparticles for Lymph Node-Targeted Delivery. Angew. Chem. Int. Ed. Engl. 55, 1334–1339. https://doi.org/10.1002/anie.201508626
Aloi, Antonio, Vargas Jentzsch, A., Vilanova, N., Albertazzi, L., Meijer, E.W., Voets, I.K., 2016. Imaging Nanostructures by Single-Molecule Localization Microscopy in Organic Solvents. J. Am. Chem. Soc. 138, 2953–2956. https://doi.org/10.1021/jacs.5b13585
van der Zwaag, D., Vanparijs, N., Wijnands, S., De Rycke, R., De Geest, B.G., Albertazzi, L., 2016. Super Resolution Imaging of Nanoparticles Cellular Uptake and Trafficking. ACS Appl. Mater. Interfaces 8, 6391–6399. https://doi.org/10.1021/acsami.6b00811
Aloi, A., Vilanova, N., Albertazzi, L., Voets, I.K., 2016. iPAINT: a general approach tailored to image the topology of interfaces with nanometer resolution. Nanoscale 8, 8712–8716. https://doi.org/10.1039/c6nr00445h
Beun, L.H., Albertazzi, L., van der Zwaag, D., de Vries, R., Cohen Stuart, M.A., 2016. Unidirectional Living Growth of Self-Assembled Protein Nanofibrils Revealed by Super-resolution Microscopy. ACS Nano 10, 4973–4980. https://doi.org/10.1021/acsnano.6b01017
Garzoni, M., Baker, M.B., Leenders, C.M.A., Voets, I.K., Albertazzi, L., Palmans, A.R.A., Meijer, E.W., Pavan, G.M., 2016. Effect of H-Bonding on Order Amplification in the Growth of a Supramolecular Polymer in Water. J. Am. Chem. Soc. 138, 13985–13995. https://doi.org/10.1021/jacs.6b07530

2015

Baker, M.B., Albertazzi, L., Voets, I.K., Leenders, C.M.A., Palmans, A.R.A., Pavan, G.M., Meijer, E.W., 2015. Consequences of chirality on the dynamics of a water-soluble supramolecular polymer. Nature Communications 6, 1–12. https://doi.org/10.1038/ncomms7234
de Feijter, I., Albertazzi, L., Palmans, A.R.A., Voets, I.K., 2015. Stimuli-Responsive Colloidal Assembly Driven by Surface-Grafted Supramolecular Moieties. Langmuir 31, 57–64. https://doi.org/10.1021/la5031872
Liu, Y., Pauloehrl, T., Presolski, S.I., Albertazzi, L., Palmans, A.R.A., Meijer, E.W., 2015. Modular Synthetic Platform for the Construction of Functional Single-Chain Polymeric Nanoparticles: From Aqueous Catalysis to Photosensitization. J. Am. Chem. Soc. 137, 13096–13105. https://doi.org/10.1021/jacs.5b08299

2014

Albertazzi, L., Zwaag, D. van der, Leenders, C.M.A., Fitzner, R., Hofstad, R.W. van der, Meijer, E.W., 2014. Probing Exchange Pathways in One-Dimensional Aggregates with Super-Resolution Microscopy. Science 344, 491–495. https://doi.org/10.1126/science.1250945

2013

Albertazzi, L., Gherardini, L., Brondi, M., Sulis Sato, S., Bifone, A., Pizzorusso, T., Ratto, G.M., Bardi, G., 2013a. In Vivo Distribution and Toxicity of PAMAM Dendrimers in the Central Nervous System Depend on Their Surface Chemistry. Mol. Pharmaceutics 10, 249–260. https://doi.org/10.1021/mp300391v
Albertazzi, L., Martinez-Veracoechea, F.J., Leenders, C.M.A., Voets, I.K., Frenkel, D., Meijer, E.W., 2013b. Spatiotemporal control and superselectivity in supramolecular polymers using multivalency. PNAS 110, 12203–12208. https://doi.org/10.1073/pnas.1303109110
Boni, A., Albertazzi, L., Innocenti, C., Gemmi, M., Bifone, A., 2013. Water Dispersal and Functionalization of Hydrophobic Iron Oxide Nanoparticles with Lipid-Modified Poly(amidoamine) Dendrimers. Langmuir 29, 10973–10979. https://doi.org/10.1021/la400791a
Kieltyka, R.E., Pape, A.C.H., Albertazzi, L., Nakano, Y., Bastings, M.M.C., Voets, I.K., Dankers, P.Y.W., Meijer, E.W., 2013. Mesoscale Modulation of Supramolecular Ureidopyrimidinone-Based Poly(ethylene glycol) Transient Networks in Water. J. Am. Chem. Soc. 135, 11159–11164. https://doi.org/10.1021/ja403745w
M. Pavan, G., Barducci, A., Albertazzi, L., Parrinello, M., 2013. Combining metadynamics simulation and experiments to characterize dendrimers in solution. Soft Matter 9, 2593–2597. https://doi.org/10.1039/C3SM27706B